UKAS LAB · HARLEY STREET

Hughes Syndrome Blood Test

Recurrent miscarriages. Blood clots without explanation. A stroke in your 30s or 40s. If you've been searching for answers and coming up empty, Hughes Syndrome may be the diagnosis that changes everything.

General Medical Council registered doctors

Est. 1984

Care Quality Commission

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Hughes syndrome blood test in London

The Hughes syndrome blood test at Medical Express Clinic screens for antiphospholipid syndrome (APS), an autoimmune condition in which antibodies make blood clot too easily.

Hughes syndrome is one of the most common causes of recurrent pregnancy loss and unexplained clots in younger adults, yet many people go years without diagnosis.

The Hughes syndrome test checks for lupus anticoagulant and anticardiolipin antibodies (IgG and IgM).

Hughes syndrome testing is appropriate after two or more unexplained miscarriages, blood clots (DVT or PE) without clear cause, or a stroke or TIA, especially under age 50.

The Hughes syndrome blood test costs £151.25, with a GP consultation £150 extra, and results take 2 working days.

A positive Hughes syndrome result needs repeat testing after 12 weeks to tell persistent antibodies apart from temporary rises caused by infection.

No referral is needed for a private Hughes syndrome test, which can be booked online or arranged on a walk-in basis 7 days a week at 117a Harley Street, London.

Services and prices

How much does a Hughes syndrome test cost in London?

A Hughes syndrome blood test costs £151.25 at Medical Express Clinic, covering lupus anticoagulant and anticardiolipin antibodies, with results in 2 working days; a GP consultation is £150 extra.

Hughes Syndrome Blood Test

£151.25
  • Results: 2 working days
  • Laboratory report; GP consultation £150 extra
  • Walk-in available 7 days

Testing is appropriate if you have experienced:

  • • Two or more unexplained miscarriages
  • • Blood clots (DVT or PE) without clear cause
  • • Stroke or TIA, especially under age 50
  • • Livedo reticularis (mottled skin pattern)
  • • Migraines with visual disturbance

A positive result requires confirmation with repeat testing after 12 weeks to distinguish persistent antibodies from temporary elevations caused by infection.

The good news: Once diagnosed, Hughes Syndrome is treatable. Anticoagulation therapy significantly reduces the risk of further clots and pregnancy loss. Many women with Hughes Syndrome go on to have successful pregnancies with appropriate treatment.

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Clinical lead
Dr Penny Sheehan

Dr Penny Sheehan

Health Screening, Paediatrics and Menopause • GMC 6056535

“Dr Sheehan works in women's health, menopause care and health screening. She has training and experience in weight management, including GLP-1 receptor agonist prescribing, and a special interest in paediatric assessment.”

Service information reviewed 26 August 2026.

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FAQs

Hughes syndrome test FAQs

Why haven't I been tested before?

Hughes Syndrome is underdiagnosed because symptoms mimic other conditions. Many patients are only tested after multiple events. You don't need a referral to test privately.

What happens if my test is positive?

Our GP will review your result and discuss the need for confirmatory testing in 12 weeks. If confirmed, referral to a rheumatologist or haematologist for management is typically recommended.

Can Hughes Syndrome be cured?

It's managed rather than cured. With appropriate treatment (usually blood-thinning medication), most people live normal lives with significantly reduced risk of complications.

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