117a Harley St, London. Est 1984.
Private weight loss injections are prescription-only GLP-1 medicines. Our Harley Street doctors assess you in person, review baseline blood tests, and provide structured follow-up when treatment is clinically appropriate.
Est. 1984
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Private weight loss injections at Medical Express Clinic start with an in-person assessment on Harley Street, where a GMC-registered doctor decides with you whether a prescription-only GLP-1 medicine such as Mounjaro (tirzepatide) is appropriate.
The Medical Express Clinic weight-management service is for adults aged 18 and over, with suitability confirmed by the doctor, and doctors may consider Mounjaro where BMI is 30 or above, or 27 or above with a weight-related condition such as type 2 diabetes, high blood pressure or high cholesterol.
The £650 clinical package includes a consultation and physical examination, a full body composition scan, a baseline blood panel (full blood count, kidney function, liver function, lipids and HbA1c), four reviews at weeks 4, 8, 12 and 16 with diet and lifestyle support, and direct access to your doctor between appointments.
Mounjaro pens are not included in the £650 package and are paid separately at a pharmacy, from about £200 per pen, if a prescription is issued.
A Mounjaro prescription is issued only after the doctor has seen you and reviewed your history, examination and baseline tests, and meeting a BMI threshold does not guarantee treatment.
The General Pharmaceutical Council says weight-management medicines should not be prescribed from an online questionnaire alone, and expects the prescriber to verify information such as weight, height or BMI independently first.
First weight-management appointments take about 45 minutes and run Monday to Friday at 117a Harley Street, London, and can be booked online.
The doctor-led weight loss injection package at Medical Express Clinic costs £650, covering the consultation and examination, a body composition scan, a baseline blood panel, four reviews at weeks 4, 8, 12 and 16 and direct doctor access, with Mounjaro pens paid separately at a pharmacy from about £200 per pen if prescribed.
The first visit is where your doctor helps you decide whether Mounjaro is appropriate, including if you have already used a remote prescribing service and want structured, in-person support instead.
It is for adults aged 18 and over who want medically supervised weight management and are prepared to attend in person. Doctors may consider Mounjaro where body mass index is 30 or above, or 27 or above with a weight-related condition such as type 2 diabetes, high blood pressure or high cholesterol.
Meeting a BMI figure does not mean treatment will be offered. Your doctor also reviews your history, examination, blood results, current medicines and whether you can attend the planned reviews.
If you mainly want a wider health check first, start with a private GP consultation or compare private blood tests. The service below is for people specifically considering supervised weight-management treatment.
Some patients come after using a remote prescribing service and want a Harley Street doctor who can examine them, review baseline blood tests and stay available when side effects appear. At Medical Express Clinic that doctor has already seen you and checked your bloods before any prescription is decided, and remains available when questions arise.
The £650 fee is for clinical care: the assessment, the tests that help the doctor decide, and the reviews that follow if treatment starts. The injection pens are separate, because dose and duration vary from person to person.
£650
If a prescription is issued, pens start from about £200 each at a pharmacy. Later pens are also paid separately, because dose and duration vary. We cannot quote a fixed medicine total in advance.
The same £650 figure is used on the booking path. Other clinic fees are listed separately on the fees page.
The first visit is a conversation and an examination, so the doctor can decide whether a prescription is appropriate. Bring a list of medicines and any recent results you already have.
Appointments run Monday-Friday at 117a Harley Street. Allow about 45 minutes for the first visit.
Your doctor takes a history, examines you and reviews current medicines before deciding whether treatment is appropriate.
The included panel looks at blood count, kidney and liver function, cholesterol and related fats, and HbA1c. Those results help the doctor decide whether treatment can be considered safely.
A full body composition scan records a starting point for fat, including visceral fat, and muscle mass. Later reviews can then look at how your body has changed, not only the number on the scales.
If a GLP-1 weight-loss treatment is offered, you still have the same doctor at the later reviews. That is where dose, side effects, food and activity are looked at together, and where treatment can be adjusted or stopped.
Mounjaro (tirzepatide) is a GLP-1 weight-loss injection, given once a week under the skin when prescribed. It is a prescription-only medicine, issued only after the assessment and only if it remains clinically appropriate.
If treatment starts, the usual licensed approach is to begin at a low weekly dose and increase it gradually if you tolerate it. Your doctor sets that schedule, so you should not treat any published dose table as a personal plan.
The same doctor reviews you at weeks 4, 8, 12 and 16. Those visits include diet and lifestyle support, a check on side effects, and a decision on whether to adjust the dose, continue or stop. You also have direct access to your doctor between appointments.
Clinical lead for this service is Dr Penny Sheehan, GMC 6056535. You can read her clinic profile on meet the team.
Common stomach effects can occur, and one reason people want a doctor nearby is so they do not have to work out alone whether those effects are manageable. Tell your doctor if they persist or make it hard to eat and drink, so the dose or treatment can be changed if needed.
Common effects include nausea, vomiting, diarrhoea, constipation and abdominal pain. People with diabetes who also take insulin or a sulfonylurea can develop low blood sugar. These effects are not trivial. Tell your doctor if they persist or make it hard to eat and drink.
Seek urgent medical help for severe, persistent abdominal pain. If you inject more than prescribed, contact your doctor or go to hospital.
We do not start Mounjaro in type 1 diabetes, because that sits outside the weight-management licence, and we do not prescribe it in pregnancy.
If you are breastfeeding or planning a pregnancy, your doctor must discuss whether treatment is suitable and what the alternatives are.
The programme is for adults aged 18 and over, and your doctor confirms suitability. Treatment is not started if you have a known allergy to the ingredients.
Always tell your doctor about pancreatic disease, a severe gut problem such as gastroparesis, heart, kidney, liver, gallbladder or thyroid conditions. Your doctor reviews those individually and may still decide against treatment after seeing you.
New, severe or rapidly worsening illness needs a same-day GP or emergency assessment, not this programme. This service does not replace urgent care.
If the doctor decides not to start the full weight-management programme, you will only be charged for clinical services already provided.
Your doctor reviews you at the planned visits, supports you with side effects, and can stop treatment if the medicine is not right for you. Nobody can honestly tell you how much weight you will lose.
Trial averages for tirzepatide are population figures. They do not tell your doctor how much weight you will lose, or whether you will lose weight at all. Some people notice appetite change in the first few weeks. Many do not. Response depends on starting weight, tolerability, other conditions and what you can sustain with food and activity.
Your doctor reviews progress at the four included appointments and can stop treatment if it is not tolerated or no longer appropriate. How long anyone stays on an injection is an individual clinical decision, not a package length.
If the assessment shows a different problem, or if weight management is better handled without this medicine, Medical Express Clinic can keep that conversation inside the same practice. Women's health questions that sit alongside weight, such as hormonal care, can be discussed through our women's health services where relevant.
Speak to a GMC-registered doctor on Harley Street about whether supervised weight management is appropriate. Prescription-only treatment is supplied only after in-person assessment.
Book your consultationClinical package £650. Mounjaro pens are purchased separately if prescribed.
Health Screening, Paediatrics and Menopause • GMC 6056535
“Dr Sheehan works in women's health, menopause care and health screening. She has training and experience in weight management, including GLP-1 receptor agonist prescribing, and a special interest in paediatric assessment.”
Service information reviewed 26 August 2026.
Written by Mr Stephen Lingam and reviewed by a named, GMC-registered doctor.
A prescription is issued only when a doctor has seen you, reviewed your history, examination and baseline tests, and decided the medicine is appropriate. A prescription is never guaranteed. Meeting a BMI threshold does not guarantee treatment.
The £650 fee covers clinical care only: an in-person consultation and examination, a body composition scan, a baseline blood panel (full blood count, kidney function, liver function, lipids and HbA1c), four reviews at weeks 4, 8, 12 and 16 with diet and lifestyle support, and direct access to your doctor between appointments. Mounjaro pens are not included and start from about £200 each at a pharmacy if prescribed.
Adults aged 18 and over may be considered when BMI is 30 or above, or 27 or above with a weight-related condition such as type 2 diabetes, high blood pressure or high cholesterol. Suitability is confirmed in person. We do not start Mounjaro in type 1 diabetes, and we do not prescribe it in pregnancy. If you are breastfeeding or planning a pregnancy, your doctor must discuss suitability and alternatives.
You are examined on Harley Street, have baseline blood tests and a body composition scan before any prescription is decided, and the same doctor reviews you at weeks 4, 8, 12 and 16. Online questionnaire services typically do not provide that in-person assessment.
Nausea, vomiting, diarrhoea, constipation and abdominal pain are common. Seek urgent help for severe, persistent abdominal pain. People with diabetes on insulin or a sulfonylurea can develop low blood sugar.
Clinical trial averages are not a promise for any person. Your doctor monitors response and tolerability at the included reviews and can adjust or stop treatment. We do not guarantee a specific amount of weight loss.
Duration depends on your health, response, side effects and whether continued treatment remains appropriate. That decision is made at review appointments, not as a fixed course sold with the £650 package.
Allow about 45 minutes. Appointments are available Monday-Friday at 117a Harley Street.
